study the dynamics of genetic information, and how it affects evolution, behavior, and disease
ABOUT MY WORK
The aim of my research is to develop the warranted technology and algorithms in order to delineate the full extent of RNA editing in human and animal models, determine the global editing levels in various physiological and pathological conditions, develop an affordable and accurate genomic wide screen and to understand their biological function, mainly in the nervous system and the role of editing in primate evolution.
SELECTED PUBLICATIONS
1. Paz-Yaacov N, Levanon E.Y., Nevo E, Kinar Y, Harmelin A, Jacob-Hirsch J, Amariglio N, Eisenberg, G. Rechavi. Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates. PNAS. 2010
2. Zaranek AW, Levanon E.Y.*, Zecharia T, Clegg T, Church GM. A survey of genomic traces reveals a common sequencing error, RNA editing, and DNA editing. PLoS Genetics. 2010
*equal contribution with first author
3. Li J.B., Levanon, E.Y.*, J.K. Yoon, J. Aach, B. Xie, E. LeProust, K. Zhang, Y. Gao and G.M. Church. Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. Science. 2009
*equal contribution with first author
4.Paz, N., Levanon, E.Y., N. Amariglio, AB. Heimberger, Z. Ram, S. Constantini, Z.S. Barbash, K. Adamsky, M. Safran, A. Hirschberg, M. Krupsky, I. Ben-Dov, S. Cazacu,T. Mikkelsen, C. Brodie, E. Eisenberg and G. Rechavi. Altered adenosine to inosine RNA editing in human cancer. Genome Research. 2007
5. Levanon, E.Y., M. Hallegger, Y. Kinar, R. Shemesh, K. Djinovic-Carugo, G. Rechavi, M. F. Jantsch and E. Eisenberg. Evolutionarily conserved human targets of adenosine to inosine RNA editing. Nucleic Acids Research 2005
RESEARCH PROJECTS
1. RNA Editing
2. Alternative splicing
3. DNA editing of mammalian genomes
4. Somatic Activity of Retrotransposons in Human