Prof. Hanoch Senderowitz of the Department of Chemistry focuses on the development, implementation and application of new computational methodologies for the design of new and improved drugs. Such methods have been shown in the past to greatly accelerate drug design efforts (e.g., the design of HIV protease inhibitors to combat the AIDS epidemic) and so could potentially help in providing a timely response to rapidly emerging epidemic threats.
ABOUT MY WORK
modeling the structure and mode of action of pharmaceutically relevant bio-targets, studying the factors governing the interactions between such targets and their potential ligands and predicting the pharmacological profile of drug candidates, all in order to develop better drugs
1.Kalid, O., Mense, M., Fischman, S., Shitrit, A., Bihler, H., Ben-Zeev, E., … & Wetmore, D. R. (2010). Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening. Journal of computer-aided molecular design, 24(12), 971-991.
2. Noy, E., & Senderowitz, H. (2011). Combating cystic fibrosis: In search for CF transmembrane conductance regulator (CFTR) modulators. ChemMedChem, 6(2), 243-251.
3.Kahremany, S., Livne, A., Gruzman, A., Senderowitz, H., & Sasson, S. (2015). Activation of PPARδ: from computer modelling to biological effects. British journal of pharmacology, 172(3), 754-770.
4.Getter, T., Zaks, I., Barhum, Y., Ben‐Zur, T., Böselt, S., Gregoire, S., … & Shubely, M. (2015). A Chemical Chaperone‐Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS). ChemMedChem, 10(5), 850-861.
5.Aped, P., Fuchs, B., Goldberg, I., Senderowitz, H., Schleifer, L., Tartakovsky, E., … & Borremans, F. A. (1991). Structure, conformation and stereoelectronics of 9, 10-annelated-1, 4, 5, 8-tetraoxadecalins: A multidisciplinary probe. Tetrahedron, 47(30), 5781-5796.
Multi Drug Resistance (MDR)
Cystic Fibrosis (CF): Searching for the Cure
Developing New Optimization Tools
Drug Discovery, Design, and Delivery Research